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The Cambridge Centre for Ageing and Neuroscience (Cam-CAN) is a large-scale collaborative research project, launched in October 2010, with substantial funding from the Biotechnology and Biological Sciences Research Council (BBSRC).

The Cam-CAN project is using epidemiological, behavioural, and neuroimaging data to understand how individuals can best retain cognitive abilities into old age. Darren Price and the Cam-CAN team have shown that age-related delay of the brain’s response to visual stimulation is partly explained by damage to information-carrying white matter fibres.

Through new funding from the EU Horizon 2020 framework, Cam-CAN will join 10 other European cohorts in the Life Brain project to study brain change across the lifespan.

The result will be a unique multinational resource of approximately 18,500 individuals that will allow investigation of cognitive and mental health throughout life.

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Our ability to sense the environment is known to decline as we grow older.

However, a new Cam-CAN study led by Noham Wolpe finds that the brain’s motor system compensates for this change by relying more strongly on prediction from prior experience.

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These findings provide insights into why some skills are more vulnerable to age-related decline while others are preserved.

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